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About Big Data, Genes, and Medicine Course
This course distills for you the expert knowledge and abilities attained by experts in Bioinformatics and Health Big Data Science. The biology, chemistry, genetics, and medical aspects of the human body will be integrated with the science of big data, and you’ll learn how to use the wealth of data that is at your disposal and that we are only now beginning to make sense of. We’ll look into the various steps needed to master big data analytics on actual datasets, such as Next Generation Sequencing data, in the context of healthcare and biology, from getting the data ready for analysis to finishing the analysis to deriving conclusions, visualizing them, and sharing the conclusions.
You will obviously be well-positioned to apply for or advance to careers in biomedical data analytics and bioinformatics once you have mastered these in-demand abilities. Regardless of your technical or biomedical skill levels, you will learn extremely valuable new or honed skills that will set you apart as a professional and inspire you to go even further into biomedical Big Data. I hope this course will pique your curiosity about the huge opportunities provided by readily accessible Big Data to better comprehend, prevent, and treat diseases.
SKILLS YOU WILL GAIN
- Bioinformatics
- Data Clustering Algorithms
- Big Data
- R Programming
Course Apply Link – Big Data, Genes, and Medicine
Big Data, Genes, and Medicine Quiz Answers
Week 01
DNA, RNA, Genes, and Proteins
Q1. The sequence “GTGAGCACCGTGCTGACCTCCAAATACCGTTAAGCTGGAGCCTCGGTGGC” can be a fragment of (check only one):
- Protein
- RNA
- DNA
Q2. Compare and contrast the different types of RNA in a cell by finding the one FALSE answer among the following:
- rRNA, or ribosomal RNA, is located in the ribosomes and an integral part of them (60%).
- tRNA, or transfer RNA, assists in the mRNA translation, by carrying each new amino acid to the growing end of a protein being created.
- Each aminoacid has its specific ribosomal rRNA in a ribosome.
- mRNA, or messenger RNA, is the one which specializes in coding for proteins.
Transcription and Translation Processes
Q1. What is the RNA sequence complementary to the DNA sequence “AGAATCGGGACA”
- “TCTTAGCCCTGT”
- “AGAATCGGGACA”
- “UCUUAGCCCUGU”
- “AGAAUCGGGACA”
Q2. Which of the following codons have a different amino acid associated with them (you may use the protein wheel to do the translation)?
- AUU
- AUG
- AUA
- AUC
Q3. Which of the following biological macromolecules will never contain a “Tyrosine” subunit? Choose all that apply.
- RNA
- DNA
- Protein
Data, Variables, and Big Datasets
Q1. What kind of data is represented by the Gender (Male / Female) and Insurance (Medicare / Medicaid / Blue Cross / Commercial / Other) variables? Choose all that apply. (Hint: Focus on the nature of the data contained by the variable rather than the graphical display of that data).
- Categorical
- Nominal
- Numeric
Q2. What kind of data would most likely be represented by a Body Temperature (°C) variable? Choose all that apply.
- Interval
- Ratio
- Nominal
- Ordinal
Working with cBioPortal
Q1. To answer the following question, submit a query using a “User-defined List” as input at www.cbioportal.org, with the “tcga” cancer study tag entered:
Querying JAK2 on cBioPortal, what accounts for the majority of its alteration in GBM (TCGA 2008)? Hint: see the “Overview” tab.
- Amplification
- Deletion
- Mutation
Q2. To answer the following question, submit a query using a “User-defined List” as input at www.cbioportal.org, with the “tcga” cancer study tag entered:
Querying EGFR ERBB2 ERBB3 ERBB4 on cBioPortal, which of the following mutation types does ERBB2 exhibit the most often? Hint: see the “Mutations” tab.
- Truncating
- Missense
- In-frame
Q3. To answer the following question, submit a query using a “User-defined List” as input at www.cbioportal.org, with the Breast Invasive Carcinoma (TCGA, Cell 2015) dataset selected. Then, make sure to select “mRNA Expression data z-Scores (RNA Seq V2 RSEM)” with a z-score threshold of 2.0:
Querying JAK2 on cBioPortal, how is the JAK2 gene mRNA mostly dysregulated? Hint: see the “OncoPrint” tab.
- Downregulated
- Upregulated
Week 02
Datasets and Files
Q1. Which of the following is an example of a File?
- An Excel spreadsheet
- A cell in an Excel spreadsheet
- A row in an Excel spreadsheet
- A column in an Excel spreadsheet
Q2. A CSV file uses a special character to separate between fields. Which of the following are commonly used separator characters?
- Character “a”
- A tab
- A space
- A comma
Data Preprocessing Tasks
Q1. Data preprocessing tasks include (choose all that apply):
- Discretizing variables
- Replacing missing values
- Normalizing data
- Adding variables
- Imputing missing values
Q2. Which of the following is a type of data reduction?
1 point
- Data normalization
- Feature selection
- Data imputation
- Data understanding
Normalization and Discretization
Q1. When normalizing the dataset [10, 20, 30, 40, 50] through Z-score normalization, which of the following elements would be normalized to 0?
- 20
- 10
- 40
- 50
- 30
Q2. Consider the data [2, 4, 8, 16] discretized by equal-depth binning. Which of the following is a valid set of equal-depth bin intervals for these data?
- [2, 3], [4, 16]
- [2, 7], [8, 16]
- [1, 5], [6, 10], [11, 15], [16, 20]
- [2, 8], [9, 16]
Data Reduction
Q1. When sampling a dataset [10, 20, 30, 40, 50, 60, 70, 80, 90] with Simple Random Sampling With Replacement, which samples can we obtain? Choose all that apply.
- [10]
- [20, 40, 40]
- [30, 30, 30, 30]
- [10, 50, 60]
Q2. When sampling a dataset [10, 10, 20, 30] with Simple Random Sampling Without Replacement, which samples can we obtain? Choose all that apply.
- [10, 20, 20]
- [10, 20, 30]
- [10, 10, 20]
Working with R
Q1. The code below loads a previously installed package into R.
library(examplePackage)
Which of the following is not a conventional way to install an R package?
- From Bioconductor, or another contributed package resource
- Directly from The Comprehensive R Archive Network install.packages()
- Purchasing an annual proprietary license for CRAN
Q2. Which of the following statements about Anaconda is not true?
- Anaconda can provide a Jupyter notebook written in Python to run scripts online.
- Anaconda provides R by default.
- Anaconda is a set of tools for data science.
Week 03
Feature Selection Methods
Q1. With a dataset having 4 features, how many different subsets of features are there
1 point
- 16
- 8
- 4
- 2
Q2. Which of the following are examples of feature selection methods? Choose all that apply.
- Log transformation.
- Filter methods.
- Student’s t-test.
- Wrapper methods.
Differentially Expressed Genes
Q1. Which of the following statements is FALSE regarding the identification of deferentially expressed genes?
- Identifying differentially expressed genes requires more than one subject in each population examined.
- Identifying differentially expressed genes requires one and only one population (e.g., diseased subjects).
- Identifying differentially expressed genes requires the consideration of multiple expression levels across multiple subjects.
Q2. What do you think could cause a gene to express differentially when a person has a particular disease when compared with normal subjects?
Heatmaps
Q1. Which of the following best describes the axes of a heatmap?
- One axis may show genes while the other axis may show gene expression.
- One axis may show subjects while the other axis may show gene expression.
- One axis shows genes while the other axis shows subjects.
Q2. Which of the following illustrates an example of a heatmap?
- .
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- .
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- .Correct answer
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Week 04
Overview
Q1. At which stage of Big Data analytics are classification and prediction methods used?
- Domain understanding
- Data understanding
- Data preparation
- Model building
- Training and evaluation
- Deployment
Q2. When building a classifier, which of following steps are required at a minimum? Choose all that apply.
- Training step
- Test step
Classification with Analogy
Q1. Which of the following correctly describes a support vector machine (SVM) algorithm? Choose all that apply.
- It uses a kernel function to solve non-linear problems as if they were linear.
- It uses an ensemble of decision trees to separate classes.
- It aims at finding an optimal hyperplane to separate objects into separate classes.
Classification based on Rules
Q1. Which of the following best describes a decision tree?
- It requires the user to specify known class labels for the training step.
- It uses the analogy of the brain organization to create a tree.
- It builds a tree that is as compact as possible proceedings from bottom to top.
Classification with Neural Networks
Q1. Which of the following correctly describes a neural network?
- An input layer, one or several hidden layers, and an output layer are required to solve complex problems.
- It uses prior probabilities to calculate the classification rule.
- It uses a kernel function to solve non-linear problems as if they were linear.
Classification based on Statistics
Q1. Which of the following are statistical methods for classification? Choose all that apply.
- Generalized Linear Models (GLM)
- Bayesian network
- Logistic regression
Classification based on Probabilities
Q1. Which of the following are names for probabilistic models? Choose all that apply
- Graphical models
- Generalized Linear Models (GLM)
- Bayesian networks
- Decision trees
Prediction Models
Q1. Consider the scenario where a researcher uses neural networks to predict the presence or absence of cancer from measured variables. This is an example of which of the following models?
- Classification
- Prediction
- Clustering
Week 05
Gene Alterations
Q1. Which of the following are main effects of gene alterations? Choose all that apply.
- Underexpression of the corresponding gene
- Replacement of a chromosome
- Repression of a transcript
- Overexpression of the corresponding gene
- Creation of different forms of proteins
Q2. Which of the following terms best describes a genetic event in which the part of one chromosome combines with part of another chromosome?
- Silent mutation
- Translocation
- Missense mutation
- Nonsense mutation
Gene Mutations
Q1. Which terms describe the type of mutation shown in the following figure? Choose all that apply.
![Big Data, Genes, and Medicine Coursera Quiz Answers 2022 | All Weeks Assessment Answers [💯Correct Answer] 6 ngcb33](https://networkingfunda.com/ezoimgfmt/d3c33hcgiwev3.cloudfront.net/imageAssetProxy.v1/e-d7PG7mEeaPLRIThVfRHQ_435c1c0de311d8b86fe8d7af355d8ae5_nonsenseMutation.jpg?expiry=1656460800000&hmac=B8S6vZveiY7aumuOLId3YUxbLd2K_5a0ybgRNvHfduQ&ezimgfmt=rs:293x244/rscb33/ng:webp/ngcb33)
- A single point mutation
- A nonsense mutation
- A truncating mutation
- A synonymous mutation
Q2. Which of the following describes an individual homozygous for Gene A?
- The individual has two different alleles for Gene A.
- The individual has two copies of the same allele for Gene A.
Q3. To answer the following question, submit a query using a “User-defined List” as input at www.cbioportal.org, with the Uterine Corpus Endometrial Carcinoma (TCGA, Nature 2013) dataset selected. Then, make sure to select “Mutations” only:
Querying PTEN on cBioPortal, what percentage of diagnosed patients have genetic mutations for this gene? Hint: see the “OncoPrint” tab.
Copy Number Alterations
Q1. Which of the following events would most likely lead to over-expression of Gene A?
1 point
- Repression of Gene A through DNA methylation.
- A synonymous mutation in the coding portion of Gene A.
- A decrease in the copy number of Gene A.
- An increase in the copy number of Gene A.
Q2. Which of the following accurately describes the difference between gene amplification and gene copy number gain?
- The number of copies of a gene in gene amplification is much smaller than in gene copy number gain.
- The number of copies of a gene in gene amplification is much larger than in gene copy number gain.
Genomic Alterations and Gene Expressions
Q1. To answer the following question, submit a query using a “User-defined List” as input at www.cbioportal.org, with the Uterine Corpus Endometrial Carcinoma (TCGA, Nature 2013) dataset selected. Then, make sure to select “mRNA Expression data z-Scores (RNA Seq V2 RSEM)” with a z-score threshold of 2.0:
Querying EGFR on cBioPortal, what percentage of diagnosed patients have genetic mutations, copy number variations, or gene expression alterations for this gene? Hint: see the “OncoPrint” tab.
Q2. To answer the following question, submit a query using a “User-defined List” as input at www.cbioportal.org, with the Uterine Corpus Endometrial Carcinoma (TCGA, Nature 2013) dataset selected. Then, make sure to select “mRNA Expression data z-Scores (RNA Seq V2 RSEM)” with a z-score threshold of 2.0:
Querying EGFR on cBioPortal, which of the following is true about this gene? Hint: see the “OncoPrint” tab.
- Most gene alterations are truncating mutation events.
- Most gene alterations are mRNA upregulation events.
- Most gene alterations are amplification events.
- Most gene alterations are missense mutation events.
Week 06
Clustering
Q1. Which of the following best describes a cluster?
- A type of supervised learning method.
- A group of users of data analytics services.
- A group of data within a dataset.
Q2. Which of the following are criteria used for assessing the performance of a clustering method? Choose all that apply.
- Robustness to noise
- Understandability
- Scalability
Q3. What is the Euclidean distance between the two points (1, 3) and (1, 4) in a dataset?
Clustering Methods
Q1. Which of the following statements correctly apply to KMeans clustering? Choose all that apply.
- The centroid of a cluster is calculated as the average of the samples in that cluster.
- KMeans clustering is robust to outliers.
- KMeans automatically determines the optimal number of clusters in a dataset.
Q2. Which of the following statements correctly apply to density-based clustering? Choose all that apply.
- Clusters can have any shape.
- It is a computationally expensive clustering algorithm.
- The centroid of a cluster is calculated as the median of the samples in that cluster.
Q3. Hierarchical clustering that starts from the whole dataset and progressively creates clusters of smaller and smaller size is called:
- Divisive
- Agglomerative
Pathways
Q1. A cis-regulatory circuit involves:
- Upstream regulation factors not located close to the gene being regulated.
- Only transcription factors located close to the gene being regulated.
Q2. Which of the following are databases through which known pathways can be found? Choose all that apply.
- BIOCARTA
- REACTOME
- DBSCAN
Conclusion
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Changle의 Qiu Jing 후작의 망설임을보고 Hongzhi 황제는 약간 불안해졌습니다. “말해!”
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카이센 윈즈
하지만 지금은… 죄송합니다. Fang Jifan이 말하는 것이 이제 이해가 됩니다.
999 슬롯
Hongzhi 황제는 그것을 인수하고 헌장을 열고 그것을보고 눈살을 찌푸 렸습니다.오늘 홍지황제가 걱정한 것은 중국 남서부의 민란이었다.
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마종 웨이즈 2
Fang Jifan은 Hongzhi 황제를 본 다음 Liu Jian, Li Dongyang 등을 바라 보았습니다.
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AGENCANTIK
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트리플 슬롯
그렇다면 그동안의 수고가 헛되지 않은 것입니다.
AGENCANTIK
AGENCANTIK says Sending prayers to you and your family.
블랙 맘바
Huang Daming과 여러 명의 민간인 남편이 해안을 앞뒤로 순찰했습니다.
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프라그마틱 무료
Deng Jian은 잠시 당황했다가 눈을 빛내며 행복하게 말했습니다. “젊은 주인은 젊은 주인입니다.”
슬롯 게임 무료
Zhu Houzhao는 멍한 눈으로 Fang Jifan에게 물었습니다.
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하이브 슬롯
Fang Jifan은 마음에 약간의 고통을 느꼈고 시어머니는 약간 잔인했습니다.
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슬롯 모아 무료
잿빛 얼굴을 한 류연은 삼촌이라는 말을 듣고 몸을 떨었다.
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에그슬롯
하지만 지금까지 이 추세가 계속된다면… 확실하지 않습니다.
입플 토토 사이트
출입구 안은 여전히 칠흑같이 어두웠고, 인물은 한 명도 없었다.
슬롯 머신 777
Zhu Houzhao는 벽에 부딪히기를 기다릴 수 없습니다. 이것은 절름발이, 절름발이입니다.
AGENCANTIK
AGENCANTIK says This content is great very helpful
Having read this I thought it was really informative. I appreciate you taking the time and effort to put this informative article together. I once again find myself spending a significant amount of time both reading and commenting. But so what, it was still worth it!
먹튀 검증 업체
Hongzhi 황제는 얼굴을 당기고 불쾌한 척 Fang Jifan을 노려 보았습니다.
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사설 토토 사이트
집을 사러 오는 대부분의 사람들은 부자가 아닙니다.
5 래빗스 메가웨이즈
문제의 핵심은 문제가 어디에 있는지 모른다는 것입니다.
케이 슬롯
Fu Yin Zhang이 와서 옆에 서 있었지만 그의 마음은 혼란 스러웠습니다.
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슬롯 게임 사이트
Zhu Houzhao는 고개를 저었다. “모든 조각을 조각하는 데 많은 노력이 필요했습니다.”
Appreciate it for helping out, great information.
슬롯 모아 무료
Xiao Jing은 마늘을 두드리는 것처럼 서둘러 머리를 숙였습니다.
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비바 슬롯
모두 함께 걸었고 길을 따라 탕인을 알아보는 사람들이 있었고 트러블 메이커도 따라갔습니다.모두가 수다를 떨며 무엇이 폐하의 식욕을 자극할 수 있는지 추측했습니다.
블랙 맘바
Xu Yu는 마음 속으로 한숨을 쉬었습니다. 그는… 실제로 너무 많은 것을 알고 있습니다…
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하이퍼노바 인피니티 릴스
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슬롯 정품 사이트
모두가 여전히 타협했지만 결국 Zaifu 였으므로 그는 여전히 명성을 얻었습니다.
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